Basic principles of drug design Test

1、单选题：
​The target is ______ with a specific function in the body, and the drug exerts its efficacy by combining with it.‏
选项：
A: organ
B: organization
C: biomacromolecule
D: cell
答案: 【 biomacromolecule】

2、单选题：
‎Which of the following is not a requirement for an effective drug?​
选项：
A: Interact with target
B: Binding to plasma proteins
C: Maintain an appropriate concentration at the target
D: Have enough time to interact with the target
答案: 【 Binding to plasma proteins】

3、单选题：
‎Which of the following does not fall into the category of drug-receptor interaction theory?​
选项：
A: Lipinski rule
B: Lock and key theory
C: Molecular recognition
D: Induced fit theory
答案: 【 Lipinski rule】

Lead compound discovery pathway Test

1、单选题：
‎What are the two classifications of structure-based drug design?‍
选项：
A: Direct drug design, indirect drug design
B: Fragment drug design, drug property design
C: Direct drug design, fragment drug design
D: Direct drug design,drug property design
答案: 【 Direct drug design, indirect drug design】

2、单选题：
‏Indirect drug design is based on the design of the three-dimensional structure of ____.‍
选项：
A: Receptor    
B: Protein
C: Compound
D: Ligand
答案: 【 Ligand】

3、单选题：
‌What are the ways to discover lead compounds?​
选项：
A: Screening approach
B: Structure-based drug design
C: Property-based drug design
D: All of the above
答案: 【 All of the above】

Overview of Drug Design (Part 1) Test

1、单选题：
​How many years does it take to discover modern innovative drugs?‍
选项：
A: 2-3 years   
B: 5-8 years
C: 12-15 years
D: 20-30 years
答案: 【 12-15 years】

2、单选题：
‌Modern innovative drug discovery is a research process from genes to drugs. It has gone through three stages, which of the following is not?​
选项：
A: Discovery of new targets
B: Discovery of lead compounds
C: Drug development
D: Consistency evaluation
答案: 【 Consistency evaluation】

3、单选题：
​The main methods of drug design include ().​
选项：
A: Drug design based on the interaction between the target and the drug
B: Computer aided drug design
C: Drug design based on early ADME/T evaluation
D: All of them
答案: 【 All of them】

Overview of Drug Design (Part 2) Test

1、单选题：
‌The concept of structural biology inspired by the structure of the target promoted the discovery of ______, which is the First of Class drug of Puri series antihypertensive drugs and the prototype of drug design based on ______. .‎
选项：
A: Enalapril, ligand pharmacophore
B: Captopril, structure
C: Enalapril, structure
D: Captopril, ligand pharmacophore
答案: 【 Captopril, structure】

2、单选题：
‎__________ is the main way of early drug discovery.‌
选项：
A: High-throughput screening
B: Random screening
C: Target-based screening
D: Pharmacophore model screening
答案: 【 Random screening】

3、单选题：
‌Modern drug design ideas based on the research of disease mechanisms, gene defects and other signal pathways discovered by _____ as the core reflect the new progress and new trends in the contemporary drug discovery field.​
选项：
A: Random screening
B: Combinatorial chemistry
C: Target
D: High-throughput screening
答案: 【 Target】

Unit one Test

1、单选题：
‏Modern innovative drug discovery is a research process from genes to drugs. It has gone through three stages, which of the following is not?‌
选项：
A: Discovery of new targets
B: Discovery of lead compounds
C: Drug development
D: Consistency evaluation
答案: 【 Consistency evaluation】

2、单选题：
​How many years does it take to discover modern innovative drugs?‌
选项：
A: 2-3 years    
B: 5-8 years
C: 12-15 years
D: 20-30 years
答案: 【 12-15 years】

3、单选题：
‌The concept of structural biology inspired by the structure of the target promoted the discovery of ______, which is the First of Class drug of Puri series antihypertensive drugs and the prototype of drug design based on ______.‎
选项：
A: Enalapril, ligand pharmacophore
B: Captopril structure
C: Enalapril, structure
D: Captopril, ligand pharmacophore
答案: 【 Captopril structure】

4、单选题：
‌The main methods of drug design include ()‍
选项：
A: Drug design based on the interaction between the target and the drug
B: Computer aided drug design
C: Drug design based on early ADME/T evaluation
D: All of them
答案: 【 All of them】

5、单选题：
‌Modern drug design ideas based on the research of disease mechanisms, gene defects and other signal pathways discovered by _____ as the core reflect the new progress and new trends in the contemporary drug discovery field.​
选项：
A: Random screening
B: Combinatorial chemistry
C: High-throughput screening
D: Target
答案: 【 Target】

6、单选题：
‌_________ is the main way of classic drug discovery.​
选项：
A: High-throughput screening
B: Random screening
C: Target-based screening
D: Pharmacophore model screening
答案: 【 Random screening】

7、单选题：
‏The target is ______ with a specific function in the body, and the drug exerts its efficacy by combining with it.‏
选项：
A: organ
B: organization
C: biomacromolecule
D: cell
答案: 【 biomacromolecule】

8、单选题：
‏Which of the following is not a requirement for an effective drug?‎
选项：
A: Interact with target
B: Binding to plasma proteins
C: Maintain an appropriate concentration at the target
D: Have enough time to interact with the target
答案: 【 Binding to plasma proteins】

9、单选题：
‌Which of the following does not fall into the category of drug-receptor interaction theory?‌
选项：
A: Lipinski rule
B: Lock and key theory
C: Molecular recognition
D: Induced fit theory
答案: 【 Lipinski rule】

10、单选题：
‍What are the two classifications of structure-based drug design?‌
选项：
A: Direct drug design, indirect drug design
B: Fragment drug design, drug property design
C: Direct drug design, fragment drug design
D: Direct drug design, drug property design
答案: 【 Direct drug design, indirect drug design】

11、单选题：
‏Indirect drug design is based on the design of the three-dimensional structure of ____.​
选项：
A: Receptor
B: Protein    
C: Compound
D: Ligand
答案: 【 Ligand】

12、单选题：
‍What are the ways to discover lead compounds?​
选项：
A: Screening approach
B: Structure-based drug design
C: Property-based drug design
D: All of them
答案: 【 All of them】

Classical vs. Modern Drug Discovery Test

1、单选题：
‎The following cases that are not targeted drug discovery are‌
选项：
A: Discovering gefitinib through EGFR overexpression mechanism
B: Discovered acetylsalicylic acid by relieving toothache
C: Gefitinib was discovered through EGFR activating mutation mechanism
D: Sofosbuvir was discovered through NS5B mechanism
答案: 【 Discovered acetylsalicylic acid by relieving toothache】

2、单选题：
‎The discovery and verification methods of drug targets do not include‍
选项：
A: Forward recognition method
B: Phenotypic observation
C: Reverse identification method
D: Clinical Trials
答案: 【 Phenotypic observation】

3、单选题：
‍Which of the following methods is not a classic drug discovery model?​
选项：
A: Mouse writhing model
B: Rat forced swimming model
C: Mouse water maze model
D: HERG gene expression model
答案: 【 HERG gene expression model】

Classification of Drug Targets Test

1、单选题：
‏Muscarinic acetylcholine receptors belong to​
选项：
A: Ligand-gated ion channel receptor
B: G protein coupled receptor
C: Nuclear receptor
D: Receptor tyrosine kinase
答案: 【 G protein coupled receptor】

2、单选题：
‎The substrate of monoamine oxidase B is‌
选项：
A: Serotonin
B: Norepinephrine
C: Dopamine
D: Glutamate
答案: 【 Dopamine】

3、单选题：
‍Clenbuterol is also known as Clenbuterol, which belongs to β2 adrenergic receptor‏
选项：
A: Agonist
B: Antagonist
C: Inverse agonist
D: Allosteric modulator
答案: 【 Agonist】

Hypothesis of Drug Target Test

1、单选题：
​The following are not suitable as drug targets:‏
选项：
A: Histamine receptor
B: Dihydrofolate reductase
C: Tumor necrosis factor
D: All of the above can be used as drug targets
答案: 【 All of the above can be used as drug targets】

2、单选题：
‍The following statement about the target is incorrect:‎
选项：
A: Target theory is the foundation of modern drug discovery
B: Target theory is based on the discovery of drugs through phenotypes
C: Cytokines can also become targets of drug action
D: The druggability of the target is the key to the verification of the target
答案: 【 Target theory is based on the discovery of drugs through phenotypes】

3、单选题：
​The research hypothesis of the second-generation anti-tumor drug imatinib is‎
选项：
A: Philadelphia chromosome aberration and BCR-ABL fusion gene expression
B: Tumor angiogenesis
C: EGFR level overexpression
D: p53 tumor suppressor gene inactivation
答案: 【 Philadelphia chromosome aberration and BCR-ABL fusion gene expression】

Relevance of Drug Targets Test

1、单选题：
​Regarding the druggability statement, the following statement is correct​
选项：
A: GPCR-like membrane protein receptors belong to the target type with lower Druggability
B: Refers to whether the target is druggable
C: The druggability of existing drug targets is low
D: High druggability without drug market targets
答案: 【 Refers to whether the target is druggable】

2、单选题：
‍For the requirements of drug targets, what is incorrect is‏
选项：
A: The signal pathway where the drug target is located must have a critical impact on the disease
B: The drug target must have a key role in the function of the signal pathway
C: The drug target must have a pocket in the structure to bind the drug
D: The drug target is a simplification of the relationship between disease and drug
答案: 【 The drug target must have a pocket in the structure to bind the drug】

3、单选题：
‌The following antihypertensive drugs that are not in the same signaling pathway as other options are​
选项：
A: Valsartan
B: Aliskiren
C: Enalapril
D: Nifedipine
答案: 【 Nifedipine】

Target concept Test

1、单选题：
‏Which of the following scientists proposed the idea of side chain that is the prototype of modern drug target theory?‌
选项：
A: Gerhard Domagk who invented Prontosil
B: Paul Janssen who invented haloperidol and fentanyl
C: Paul Ehrlich who invented Ars vannamei
D: James Black who invented propranolol and cimetidine
答案: 【 Paul Ehrlich who invented Ars vannamei】

2、单选题：
‎Which of the following technologies is not a target structural biology research technology?‍
选项：
A: Cryo-EM technology
B: NMR technology
C: X-ray single crystal diffraction technique
D: Computer tomography
答案: 【 Computer tomography】

3、单选题：
‌The following are not drug targets:‍
选项：
A: Dopamine receptor
B: Serotonin reuptake transporter
C: Amoeba
D: Tetrahydropteroate synthase
答案: 【 Amoeba】

Unit two Test

1、单选题：
‎Which of the following scientists proposed the idea of side chain that is the prototype of modern drug target theory?‏
选项：
A: Gerhard Domagk who invented Prontosil
B: Paul Janssen who invented haloperidol and fentanyl
C: Paul Ehrlich who invented Ars vannamei
D: James Black who invented propranolol and cimetidine
答案: 【 Paul Ehrlich who invented Ars vannamei】

2、单选题：
​Which of the following technologies is not a target structural biology research technology?‎
选项：
A: Cryo-EM  technology
B: NMR technology
C: X-ray single crystal diffraction technique
D: Computer tomography
答案: 【 Computer tomography】

3、单选题：
‎The following are not drug targets‌
选项：
A: Dopamine receptor
B: Serotonin reuptake transporter
C: Amoeba
D: Tetrahydropteroate synthase
答案: 【 Amoeba】

4、单选题：
‎The following are not suitable as drug targets‏
选项：
A: Histamine receptor
B: Dihydrofolate reductase
C: Tumor necrosis factor
D: All of the above can be used as drug targets
答案: 【 All of the above can be used as drug targets】

5、单选题：
‍The following statement about the target is incorrect.‎
选项：
A: Target theory is the foundation of modern drug discovery
B: Target theory is based on the discovery of drugs through phenotypes
C: Cytokines can also be targets of drug action
D: The druggability of the target is the key to the verification of the target
答案: 【 Target theory is based on the discovery of drugs through phenotypes】

6、单选题：
‍The research hypothesis of the second-generation anti-tumor drug imatinib is‏
选项：
A: Philadelphia chromosome aberration and BCR-ABL fusion gene expression
B: Tumor angiogenesis
C: EGFR level overexpression
D: Inactivation of p53 tumor suppressor gene
答案: 【 Philadelphia chromosome aberration and BCR-ABL fusion gene expression】

7、单选题：
‎Muscarinic acetylcholine receptors belong to‎
选项：
A: Ligand-gated ion channel receptor
B: G protein coupled receptor
C: Nuclear receptor
D: Receptor tyrosine kinase
答案: 【 G protein coupled receptor】

8、单选题：
‌The substrate of monoamine oxidase B is‎
选项：
A: Serotonin
B: Norepinephrine
C: Dopamine
D: Glutamate
答案: 【 Dopamine】

9、单选题：
‍Clenbuterol, a wheezing drug that belongs to β2 adrenergic receptor, also known as clenbuterol‍
选项：
A: Agonist
B: Antagonist
C: Inverse agonist
D: Allosteric modulator
答案: 【 Agonist】

10、单选题：
​Regarding the druggability statement, which statement is correct:‌
选项：
A: GPCR-like membrane protein receptors belong to the target type with lower Druggability
B: Refers to whether the target is druggable
C: Low druggability of listed drugs targets
D: High druggability without listed drugs targets
答案: 【 Refers to whether the target is druggable】

11、单选题：
​For the requirements of drug targets, what is incorrect is:‏
选项：
A: The signal pathway where the drug target is located must have a critical impact on the disease
B: The drug target must have a key role in the function of the signal pathway
C: The drug target must have a pocket in the structure to bind the drug
D: The drug target is a simplification of the relationship between disease and drug
答案: 【 The drug target must have a pocket in the structure to bind the drug】

12、单选题：
‎The following antihypertensive drugs that are not in the same signaling pathway as other options are:‍
选项：
A: Valsartan
B: Aliskiren
C: Enalapril
D: Nifedipine
答案: 【 Nifedipine】

13、单选题：
​The following cases that are not targeted drug discovery are:‌
选项：
A: Discovering gefitinib through EGFR overexpression mechanism
B: Discovered acetylsalicylic acid by relieving toothache
C: Gefitinib was discovered through EGFR